General Information

  • ID:  hor002535
  • Uniprot ID:  NA
  • Protein name:  NPP-1 peptide
  • Gene name:  NA
  • Organism:  Schistosoma mansoni
  • Family:  NA
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  NA
  • GO MF:  NA
  • GO BP:  NA
  • GO CC:  NA

Sequence Information

  • Sequence:  GFVRI
  • Length:  5
  • Propeptide:  NA
  • Signal peptide:  NA
  • Modification:  T5 Isoleucine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  A modulatory effect on schistosome muscular activity
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    hor002535_AF2.pdbhor002535_ESM.pdb

Physical Information

Mass: 66225 Formula: C28H46N8O6
Absent amino acids: ACDEHKLMNPQSTWY Common amino acids: FGIRV
pI: 10.55 Basic residues: 1
Polar residues: 1 Hydrophobic residues: 3
Hydrophobicity: 132 Boman Index: -204
Half-Life: 30 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 136
Instability Index: 800 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  21554884
  • Title:  Schistosome I/Lamides--a New Family of Bioactive Helminth Neuropeptides